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Article

Structural Adaptability of IgA and IgM Supports Broad SARS-CoV-2 Variant Neutralization.

Journal of medical virology - 1 Jan 2026

Pisil Yalcin, Shida Hisatoshi, Ruiz Sandra Morales, Cho Kyunghak, Gungor Metehan, Yazici Zafer, Miura Tomoyuki

Abstract excerpt

Neutralizing emerging SARS-CoV-2 variants requires antibodies effective not only against epitope mutations but also under variable antigenic presentations. We assessed the neutralization capacity of the same anti-RBD monoclonal antibody (8A5) expressed as IgG, IgA, or IgM against 18 variants, identifying three neutralization classes: variants susceptible to all isotypes, variants resistant to IgG but sensitive to...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41537598
DOI: 10.1002/jmv.70790
PMCID: PMC12805870

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 18 Oct 2026.

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