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The impact of purifying selection and genetic drift on the distribution of dominance coefficients.

Evolution; international journal of organic evolution - 3 Mar 2026

Zeitler Leo, Gilbert Kimberly J

Abstract excerpt

The relationship between dominance and selection coefficients is a long-debated topic in evolutionary genetics and important for understanding evolutionary dynamics of populations. How it evolved and how it may vary across species or populations is not fully understood. Using simulations, we investigate how purifying selection and genetic drift affect the distribution of dominance coefficients for segregating...

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PMID: 41533661
DOI: 10.1093/evolut/qpaf261

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