Article
On the accumulation of deleterious mutations during range expansions.
Molecular ecology - 1 Dec 2013
Peischl S, Dupanloup I, Kirkpatrick M, Excoffier L
Abstract excerpt
We investigate the effect of spatial range expansions on the evolution of fitness when beneficial and deleterious mutations cosegregate. We perform individual-based simulations of 1D and 2D range expansions and complement them with analytical approximations for the evolution of mean fitness at the edge of the expansion. We find that deleterious mutations accumulate steadily on the wave front during range...
Topics
- Biological Evolution
- Computer Simulation
- Exome
- Genetic Fitness
- Genetics, Population
- Humans
- Models, Genetic
- Mutation