DNase1 RS1053874 Polymorphism is Associated with Early Neurological Recovery through NET Modulation and with Long-Term Survival in Ischemic Stroke: A Prospective Cohort Study.

doi:10.1002/ana.78156

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DNase1 RS1053874 Polymorphism is Associated with Early Neurological Recovery through NET Modulation and with Long-Term Survival in Ischemic Stroke: A Prospective Cohort Study.

Annals of neurology - 1 May 2026

Díaz-Benito B, Calleja P, Alzamora L, Ruiz-García A, Martínez-Salio A, Muñoz-García M, Ostos F, García-Culebras A, Moraga A, Moro M A, Lizasoain I

Abstract excerpt

OBJECTIVE: Immunothrombosis contributes to ischemic stroke pathophysiology through neutrophil extracellular trap (NET) formation, which promotes thrombus stabilization and microvascular dysfunction. DNase1 is the principal endonuclease responsible for NET degradation. The rs1053874 polymorphism in DNase1 gene influences enzymatic activity and protein stability in vitro, but its clinical relevance in ischemic...

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PMID: 41527943
DOI: 10.1002/ana.78156
PMCID: PMC13092784

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