Article
Genetic variation contributes to gene expression response in ischemic stroke: an eQTL study.
Annals of clinical and translational neurology - 1 Sept 2020
Amini Hajar, Shroff Natasha, Stamova Boryana, Ferino Eva, Carmona-Mora Paulina, Zhan Xinhua, Sitorus Preston P, Hull Heather, Jickling Glen C, Sharp Frank R, Ander Bradley P
Abstract excerpt
OBJECTIVE: Single nucleotide polymorphisms (SNPs) contribute to complex disorders such as ischemic stroke (IS). Since SNPs could affect IS by altering gene expression, we studied the association of common SNPs with changes in mRNA expression (i.e. expression quantitative trait loci; eQTL) in blood after IS. METHODS: RNA and DNA were isolated from 137 patients with acute IS and 138 vascular risk factor controls...
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