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Article

Deoxyribonuclease 1 Q222R single nucleotide polymorphism and long-term mortality after acute myocardial infarction.

Basic research in cardiology - 23 Apr 2021

Hofbauer Thomas M, Mangold Andreas, Ondracek Anna S, Panzenböck Adelheid, Scherz Thomas, Müller Julian, Distelmaier Klaus, Seidl Veronika, Kastl Stefan, Müller-Nurasyid Martina, Peters Annette, Strauch Konstantin, Winker Robert, Wohlschläger-Krenn Evelyne, Nistler Sonja, Lang Irene M

Abstract excerpt

Upon activation, neutrophils release neutrophil extracellular traps (NETs), which contribute to circulating DNA burden and thrombosis, including ST-segment elevation myocardial infarction (STEMI). Deoxyribonuclease (DNase) 1 degrades circulating DNA and NETs. Lower DNase activity correlates with NET burden and infarct size. The DNase 1 Q222R single nucleotide polymorphism (SNP), impairing DNase 1 function, is...

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Identifiers

PMID: 33891165
DOI: 10.1007/s00395-021-00864-w
PMCID: PMC8064981

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