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Article

Interplay of Large Neutral Amino Acids, Metabolic Syndrome, and Apolipoprotein E ε4 on Brain Integrity at Midlife.

Lifestyle genomics - 1 Jan 2024

Youn Cherry, Caillaud Marie L, Li Yanrong, Gallagher Isabelle, Strasser Barbara, Tanaka Hirofumi, Haley Andreana P

Abstract excerpt

INTRODUCTION: Large neutral amino acids (LNAAs) tryptophan and phenylalanine have been implicated in the pathogenesis of neurodegenerative diseases. Given limited research on the effects of LNAA on brain health across different life stages, vascular risk, and genetic backgrounds, our study aimed to explore the interaction of LNAA levels, metabolic syndrome (MetS), and the presence of the apolipoprotein E ε4 (ApoE...

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Identifiers

PMID: 39102798
DOI: 10.1159/000540336
PMCID: PMC11385466

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