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Article

Structural basis for organism-dependent effects on spectroscopic properties of type 1 copper azurin by the same axial methionine to histidine mutation.

Journal of inorganic biochemistry - 1 Apr 2026

Xu Jiaqing, Yu Lu, Yu Sheng-Song, Liu Yiwei, Wang Jing-Xiang, Li Jun-Jie, Van Stappen Casey, Yu Han-Qing, Nilges Mark J, Lu Yi

Abstract excerpt

Cupredoxins are a family of copper proteins that mediate electron transfer in key biological processes, and understanding structural features responsible for their spectroscopic properties is important for elucidating structure-function relationships. Here, we characterize the effect of mutation of the axial methionine to histidine in azurin from Pseudomonas aeruginosa (M121HAz-PA) using UV-Vis absorption,...

Topics

Azurin
Histidine
Copper
Pseudomonas aeruginosa
Electron Spin Resonance Spectroscopy
Crystallography, X-Ray
Methionine
Mutation
Bacterial Proteins
Alcaligenes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Models, Molecular

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Identifiers

PMID: 41518912
DOI: 10.1016/j.jinorgbio.2025.113209
PMCID: PMC13091565

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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