Article
Axial interactions in the mixed-valent CuA active site and role of the axial methionine in electron transfer.
Proceedings of the National Academy of Sciences of the United States of America - 3 Sept 2013
Tsai Ming-Li, Hadt Ryan G, Marshall Nicholas M, Wilson Tiffany D, Lu Yi, Solomon Edward I
Abstract excerpt
Within Cu-containing electron transfer active sites, the role of the axial ligand in type 1 sites is well defined, yet its role in the binuclear mixed-valent CuA sites is less clear. Recently, the mutation of the axial Met to Leu in a CuA site engineered into azurin (CuA Az) was found to have a limited effect on E(0) relative to this mutation in blue copper (BC). Detailed low-temperature absorption and magnetic...
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