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Article

Circulating metabolites on dental caries risk: A Mendelian randomization study.

Medicine - 9 Jan 2026

Shi Ping, Liu Xiaofen, Lei Fengzhen, Hu Ziyang, Xu Zhe

Abstract excerpt

To overcome the limitations of observational studies, this study aimed to systematically investigate the causal effects of a comprehensive panel of 1400 circulating serum metabolites on the risk of dental caries using a two-sample Mendelian randomization (MR) design. This two-sample MR study utilized genetic instruments for 1400 serum metabolites from a genome-wide association study of 8299 individuals. Genetic...

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Dental Caries
Flavin-Adenine Dinucleotide
Genome-Wide Association Study
Mendelian Randomization Analysis
Polymorphism, Single Nucleotide

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 41517706
DOI: 10.1097/MD.0000000000047090
PMCID: PMC12794991

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