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Article

Mutant Tau (P301L) Enhances Global Protein Translation in Differentiated SH-SY5Y Cells by Upregulating mTOR Signalling.

International journal of molecular sciences - 1 Jan 2026

Cipriano Giovanni Luca, Floramo Alessia, Argento Veronica, Oddo Salvatore, Artimagnella Osvaldo

Abstract excerpt

Altered protein synthesis plays a key role in ageing and multiple neurodegenerative diseases. In Alzheimer's disease and other tauopathies, the intracellular accumulation of hyperphosphorylated Tau disrupts several cellular processes, including mRNA translation. Although Tau interacts with ribosomal proteins and modulates translational selectivity, its effects on global protein synthesis remain poorly understood....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41516328
DOI: 10.3390/ijms27010455
PMCID: PMC12785925

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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