Article
Epimutation analysis reveals involvement of SLIT2/ROBO signaling pathway in painful diabetic neuropathy.
Human genomics - 9 Jan 2026
Kwiatkowska Katarzyna Malgorzata, Garagnani Paolo, Ferraresi Francesca, Bonafé Massimiliano, Bacalini Maria G, Sala Claudia, Castellani Gastone, Gentilini Davide, Calzari Luciano, Ziegler Dan, Gerrits Monique M, Faber Catharina G, Malik Rayaz A, Marchi Margherita, Salvi Erika, Lauria Giuseppe, Pirazzini Chiara
Abstract excerpt
Changes in gene function or expression caused by epigenetic modifications may play a role in painful diabetic neuropathy. Two independent cohorts of patients deeply phenotyped for painful diabetic neuropathy underwent whole genome DNA methylation data analysis. Burden of rare site events at the global, chromosomal and gene level; epigenetic homogeneity for regions enriched in epivariants (epilesions) and...
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