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Article

Generation and validation of an iPSC line HMSCATi009-A from a patient with frontotemporal dementia.

Stem cell research - 1 Feb 2026

Wang Jiaxuan, Hu Aoyu, Zhao Hongying, Cao Biqing, Wang Shan, Ma Min, Ren Qian

Abstract excerpt

The CHMP2B gene is recognized as a causative factor in neurodegenerative disorders, particularly frontotemporal dementia (FTD). In this study, peripheral blood mononuclear cells (PBMCs) were obtained from a FTD patient carrying a heterozygous CHMP2B c.532-2 (A > T) mutation and successfully reprogrammed into induced pluripotent stem cell (iPSC) line HMSCATi009-A. The resulting iPSC line exhibited a normal...

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Source

Identifiers

PMID: 41505926
DOI: 10.1016/j.scr.2025.103903

Genes

CHMP2B

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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