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Somatic and Stem Cell Bank to study the contribution of African ancestry to dementia: African iPSC Initiative.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Apr 2025

Maina Mahmoud B, Isah Murtala B, Marsh Jacob A, Muhammad Zaid, Babazau Larema, Idris Abdulrahman Alkhamis, Aladyeva Ekaterina, Miller Nadia, Starr Emma, Miller Katherine J, Lee Scott, Minaya Miguel, Wray Selina, Harari Oscar, Goni Baba W, Serpell Louise C, Karch Celeste M

Abstract excerpt

INTRODUCTION: Africa, home to 1.4 billion people and the highest genetic diversity globally, harbors unique genetic variants crucial for understanding complex diseases like neurodegenerative disorders. However, African populations remain underrepresented in induced pluripotent stem cell (iPSC) collections, limiting the exploration of population-specific disease mechanisms and therapeutic discoveries. METHODS: To...

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PMID: 40219788
DOI: 10.1002/alz.70145
PMCID: PMC11992592

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