Molecular Variations in Glycoprotein B of Asian Human Cytomegalovirus: Potential Impact on Virus Entry and Immune Evasion in Ocular Diseases.

doi:10.1002/jmv.70786

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Article

Molecular Variations in Glycoprotein B of Asian Human Cytomegalovirus: Potential Impact on Virus Entry and Immune Evasion in Ocular Diseases.

Journal of medical virology - 1 Jan 2026

Lestari Tantri, Yawata Nobuyo, Gonzalez Gabriel, Miyadera Hiroko, Motooka Daisuke, Imamura Yuko, Oki Hiroya, Mori Yasuo, Shirane Mariko, Khor Seik-Soon, Omae Yosuke, Shimada Mihoko, Windy Dyah Ayu, Nakano Satoko, Tsutsui Hiroki, Kuramoto Shiori, Fukui Chihiro, Nakamura Riku, Yamana Satoshi, Kaburaki Toshikatsu, Mashimo Hisashi, Takase Hiroshi, Yanai Ryoji, Hasegawa Eiichi, Shibata Kensuke, Yawata Makoto, Tokunaga Katsushi, Ohguro Nobuyuki, Sonoda Koh-Hei

Abstract excerpt

Human cytomegalovirus (HCMV)-associated ocular diseases have gained increasing attention due to a recent rise in cases diagnosed in Asia. A glycoprotein encoded by the virus UL55 gene, glycoprotein B (gB), is essential for viral entry and a primary target for naturally-produced antibodies and vaccine development. gB is classified into five genotypes (gB1-gB5) based on polymorphisms surrounding the furin cleavage...

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PMID: 41499312
DOI: 10.1002/jmv.70786
PMCID: PMC12778896

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