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Article

Third-generation whole-genome sequencing reveals the role of CNTNAP2 as a tumor suppressor gene in high-risk neuroblastomas.

Journal of translational medicine - 6 Jan 2026

Liu Yun, Zhao Jing, Wang Kaiyuan, Jin Yan, Gong Baocheng, Gao Mingyou, Xia Yuren, Li Jie, Zhang Xia, Shi Zhenyu, Zhang Jie, Bao Li, Zhao Qiang

Abstract excerpt

BACKGROUND: Neuroblastoma is a common and aggressive pediatric sympathetic nervous system tumor. Genomic structural variants (SVs) contribute substantially to neuroblastoma, yet remain under-characterized in high-risk neuroblastomas. We aimed to elucidate neuroblastoma pathogenesis using third-generation whole-genome sequence high-risk cases to identify driver aberrations and explore potential therapeutic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41495714
DOI: 10.1186/s12967-025-07671-0
PMCID: PMC12870515

Genes

CNTNAP2
DBN1
MYH9
CTNNB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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