Article
MUC4 mutations promote a thrombotic phenotype in patients with paroxysmal nocturnal haemoglobinuria by increasing the deposition of terminal complement.
Clinical and translational medicine - 1 Jan 2026
Chen Yingying, Che Mengting, Wang Chaomeng, Zhang Qiaoyi Bronte, Chen Weixin, Liu Hui, Liu Chunyan, Ling Guang Sheng, Fu Rong
Abstract excerpt
BACKGROUND: Thrombosis is a common complication in paroxysmal nocturnal haemoglobinuria (PNH) patients, but primary prevention remains controversial. Identifying high-risk individuals could enable risk-stratified prophylactic anticoagulation strategies. METHODS: We analyzed clinical data from PNH patients with or without thrombosis, including MUC4 mutation status and serum complement C5b-9 levels. Complement...
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