Article
Development and validation of dynamic clinical subphenotypes in acute pancreatitis patients using vital sign trajectories in intensive care units: a multinational cohort study.
Signal transduction and targeted therapy - 4 Jun 2025
Wang Zichen, Wang Wen, Xu Jiayue, He Qiao, Sun Che, Xie Shuangyi, Zou Kang, Xia Qing, Sun Xin
Abstract excerpt
Acute pancreatitis (AP) is a heterogeneous inflammatory condition. Although emerging therapeutic strategies targeting pathways such as calcium signaling, TNF-α, the NLRP3 inflammasome, and HMGB1 have shown promise, their efficacy may be limited by the underlying biological heterogeneity of the disease. In this multinational retrospective cohort study across three large ICU databases (ICU-HAI, MIMIC-IV, and...
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