Article
In silico profiling of the plasmodium knowlesi 32 kDa antigen: Diversity, epitope prediction, and structural modeling.
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases - 1 Mar 2026
Saif Ahmed, Baruah Pratisthita, Alghamdi Jawahir Marzouq, Acharyya Rudraangsh, Lau Yee Ling, Han Jin-Hee, Ahmed Md Atique
Abstract excerpt
The emergence of Plasmodium knowlesi malaria in Southeast Asia, particularly Malaysia, necessitates effective interventions. However, high polymorphism often limits the utility of key merozoite surface proteins (MSPs) as viable vaccine candidates. Pk32, a predicted glycosylphosphatidylinositol (GPI)-anchored protein in P. knowlesi, shares homology with the relatively conserved Plasmodium vivax Pv32, suggesting it...
Topics
- Plasmodium knowlesi
- Antigens, Protozoan
- Phylogeny
- Genetic Variation
- Humans
- Models, Molecular
- Malaria
- Amino Acid Sequence
- Epitopes, B-Lymphocyte
- Protozoan Proteins
- Selection, Genetic
- Epitopes