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Whole-Genome Amplification on Single Circulating Trophoblast Cell.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2026

Chakchouk Imen, Van den Veyver Ignatia B

Abstract excerpt

Whole-genome amplification (WGA) is a technique designed to amplify the entire genome from trace amounts of original template DNA, such as that from a single cell. This amplification provides sufficient DNA for downstream comprehensive genetic analysis. In cell-based noninvasive prenatal testing (cb-NIPT), single circulating trophoblast cells are isolated from the maternal bloodstream. Among the required steps in...

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PMID: 41478945
DOI: 10.1007/978-1-0716-5060-8_2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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