Article

Validation study for noninvasive single-cell-based prenatal genetic testing

2023-08-31

Abstract excerpt

<h4>Objective</h4> To clinically validate a cell-based noninvasive prenatal genetic test using sequence-based copy number analysis of single trophoblasts from maternal blood. <h4>Methods</h4> Blood was obtained from 401 individuals (8-22 weeks) and shipped overnight. Red blood cells were lysed, and nucleated cells stained for cytokeratin (CK) and CD45 using fluorescent antibodies and enriched for positive CK stain...

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Literature Corpus work: 2292f67f-b69f-596d-bf09-c5821dfbf2ee
DOI: 10.1101/2023.08.29.23294301

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