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Article

Modeling early pathophysiological phenotypes of diabetic retinopathy in a human inner blood-retinal barrier-on-a-chip.

Nature communications - 14 Feb 2024

Maurissen Thomas L, Spielmann Alena J, Schellenberg Gabriella, Bickle Marc, Vieira Jose Ricardo, Lai Si Ying, Pavlou Georgios, Fauser Sascha, Westenskow Peter D, Kamm Roger D, Ragelle Héloïse

Abstract excerpt

Diabetic retinopathy (DR) is a microvascular disorder characterized by inner blood-retinal barrier (iBRB) breakdown and irreversible vision loss. While the symptoms of DR are known, disease mechanisms including basement membrane thickening, pericyte dropout and capillary damage remain poorly understood and interventions to repair diseased iBRB microvascular networks have not been developed. In addition, current...

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Identifiers

PMID: 38355716
DOI: 10.1038/s41467-024-45456-z
PMCID: PMC10866954

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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