Association of immune relevant single nucleotide polymorphisms with ALK-positive anaplastic large cell lymphoma presentation and outcome: results of the immuno ALCL study.

doi:10.1186/s12967-025-07410-5

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Article

Association of immune relevant single nucleotide polymorphisms with ALK-positive anaplastic large cell lymphoma presentation and outcome: results of the immuno ALCL study.

Journal of translational medicine - 30 Dec 2025

Adriana Petrazzuolo, Carbonnier Vincent, De Palma Fatima Domenica Elisa, Perez-Lanzon Maria, Vergé Véronique, Quivoron Cyril, Lamant Laurence, Brugieres Laurence, Rigaud Charlotte, Ducassou Stéphane, Dourthe Marie-Emilie, Le Deley Marie-Cécile, Damm-Welk Christine, Woessmann Willi, Minard-Colin Véronique, Maiuri Maria Chiara, Kroemer Guido

Abstract excerpt

BACKGROUND: Single nucleotide polymorphisms (SNPs) of cancer-immunity relevant genes may decide the extent of tumor immunosurveillance and have clinical significance. The Immuno ALCL trial was designed to investigate whether genetic variability in 13 cancer-immunity relevant genes correlated with clinical features and outcome of anaplastic lymphoma kinase (ALK)-positive anaplastic large cell lymphoma (ALCL)...

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Identifiers

PMID: 41469691
DOI: 10.1186/s12967-025-07410-5
PMCID: PMC12754919

Genes

ALK
IL10
TLR3

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