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Article

Genomic analysis unlocks the potential of denosumab as a targeted therapy for Crohn's disease.

Scientific reports - 29 Dec 2025

Pranata Rio, Ratnasari Neneng, Bayupurnama Putut, Indrarti Fahmi, Aulia Nisma, Rahmawati Hegaria, Adikusuma Wirawan, Mugiyanto Eko, Irham Lalu Muhammad, Gunarto Christian, Alya Salma Shabira, Hadi Vanessa Felicia, Sentosa Gisella Chika, Wahyuningsih Arum Tri, Lin Chiou-Feng, Satria Rahmat Dani

Abstract excerpt

Crohn's disease (CD) is a chronic, relapsing inflammatory disorder of the gastrointestinal tract with limited curative therapies. Genomic drug repurposing offers a rapid strategy to identify existing drugs that could be redirected to treat CD. We retrieved 1,333 CD-associated single-nucleotide polymorphisms from the GWAS Catalog and expanded these to 15,590 variants using linkage disequilibrium analysis in...

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Identifiers

PMID: 41461683
DOI: 10.1038/s41598-025-28395-7
PMCID: PMC12749831

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TNFSF11

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