Tissue-specific differences of gene expression variance in mutation accumulation lines of mice.

Abstract excerpt

New mutations are the source of all genetic variation, including variation affecting quantitative phenotypes. Here, in order to evaluate the impact of mutations on the integrated function of entire tissues, we estimated the mutational variation (Vm) introduced by new mutations each generation for gene expression. Using deep transcriptome sequencing, we estimated Vm for brain and liver gene expression in...

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