Article
Cerebellar neurocan gene expression is a common pathogenic factor of trigeminal neuralgia and depression.
The journal of headache and pain - 25 Dec 2025
Zeng Zhangying, Jiang Jianwei, Wu Xuemei, Liao Xinyue, Wang Yiqian, Zhao Li, Wang Feng, Rao Shitao, Luo Daoshu
Abstract excerpt
BACKGROUND: Trigeminal neuralgia (TN) is a severe neuropathic pain disorder characterized by sudden, electric shock-like facial pain. It frequently co-occurs with depression and these conditions often exacerbate each other. However, their shared pathogenic mechanisms remain poorly understood METHODS: In this study, neuroimaging data were integrated with whole-genome sequencing data to identify common genetic risk...
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