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Article

Genomic Validation in the UK Biobank Cohort Suggests a Role of C8B and MFG-E8 in the Pathogenesis of Trigeminal Neuralgia.

Journal of molecular neuroscience : MN - 3 Oct 2024

Lafta Muataz S, Rukh Gull, Hamdeh Sami Abu, Molero Yasmina, Sokolov Aleksandr V, Rostami Elham, Schiöth Helgi B

Abstract excerpt

Trigeminal neuralgia (TN) is a severe facial pain disease of uncertain pathophysiology and unclear genetic background. Although recent research has reported a more important role of genetic factors in TN pathogenesis, few candidate genes have been proposed to date. The present study aimed to identify independent genetic variants in the protein-coding genes associated with TN. We focused on genes previously linked...

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PMID: 39361088
DOI: 10.1007/s12031-024-02263-x
PMCID: PMC11449953

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