Article

Pathophysiological Mechanisms of the Microbiota-Gut-Brain Axis in Amyotrophic Lateral Sclerosis: Intestinal Permeability, Neuroinflammation, and Therapeutic Horizons for Non-Motor Symptoms

2026-06-30

Abstract excerpt

Amyotrophic Lateral Sclerosis (ALS) is a progressive neurodegenerative disorder where systemic pathophysiological alterations significantly contribute to disease progression and non-motor manifestations, such as depression and anxiety. The microbiota-gut-brain axis represents a critical bidirectional pathway where intestinal dysbiosis and epithelial barrier disruption catalyze central neuroinflammation. This scopi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: afe5954c-888c-51b3-a838-65844e8c542e
DOI: 10.20944/preprints202606.2271.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Pathophysiological Mechanisms of the Microbiota-Gut-Brain Axis in Amyotrophic Lateral Sclerosis: Intestinal Permeability, Neuroinflammation, and Therapeutic Horizons for Non-Motor SymptomsDOI 10.20944/preprints202606.2271.v1Read

Microbial Influences on Amyotrophic Lateral Sclerosis: The Gut-Brain Axis and Therapeutic Potential of Microbiota ModulationSemantic proximity Read

The Gut Microbiota-Immunity Axis in ALS: A Role in Deciphering Disease Heterogeneity?Semantic proximity Read

The Impact of Microbiota on the Pathogenesis of Amyotrophic Lateral Sclerosis and the Possible Benefits of Polyphenols. An OverviewSemantic proximity Read

Amyotrophic Lateral Sclerosis (ALS) Genetics and Microbiota: A Comprehensive Review.Semantic proximity Read

Gut microbiota in ALS: possible role in pathogenesis?Semantic proximity Read

The gut microbiome: a key player in the complexity of amyotrophic lateral sclerosis (ALS)Semantic proximity Read

Gut Brain Axis and Neurodegenerative Diseases. Nutritional Interventions Targeting Gut Microbiome: A Systematic ReviewSemantic proximity Read

Gut Microbiota and Disorders of the Central Nervous SystemSemantic proximity Read

Bidirectional communication between the gut microbiota and the central nervous systemSemantic proximity Read

Correlation between the gut microbiome and neurodegenerative diseases: a review of metagenomics evidenceSemantic proximity Read

The human gut microbiota in people with amyotrophic lateral sclerosisSemantic proximity Read

The alteration of gut microbiome and metabolism in amyotrophic lateral sclerosis patientsSemantic proximity Read