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Article

Constitutive and hyperresponsive signaling by mutant forms of Saccharomyces cerevisiae amino acid sensor Ssy1.

Eukaryotic cell - 1 Oct 2003

Gaber Richard F, Ottow Kim, Andersen Helge A, Kielland-Brandt Morten C

Abstract excerpt

Sensing of extracellular amino acids results in transcriptional induction of amino acid permease genes in yeast. Ssy1, a membrane protein resembling amino acid permeases, is required for signaling but is apparently unable to transport amino acids and is thus believed to be a sensor. By using a novel genetic screen in which potassium uptake was made dependent on amino acid signaling, we obtained gain-of-function...

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Identifiers

PMID: 14555474
DOI: 10.1128/EC.2.5.922-929.2003
PMCID: PMC219377

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Source receipt: pubmed, retrieved 7 Sept 2026.

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