Heavy ion beam irradiation-induced mutational profiles in Saccharomyces cerevisiae and their dependencies on dose and intracellular state inform an enhanced microbial breeding strategy.

Abstract excerpt

Efficient microbial mutagenesis using heavy-ion beam (HIB) radiation is crucial for breeding. Here, Saccharomyces cerevisiae was irradiated with HIB across medium and high doses. Based on 65 randomly selected isolates, we systematically characterized the mutagenic features and preliminarily explored the influence of gene transcriptional activity on mutation susceptibility, while also modulating the intracellular...

Topics

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• Dose-Response Relationship, Radiation
• Heavy Ions
• Mutagenesis
• Mutation
• Mutation Rate