Article
Lysosomal Storage Disorders Shed Light on Lysosomal Dysfunction in Parkinson's Disease.
International journal of molecular sciences - 14 Jul 2020
Blumenreich Shani, Barav Or B, Jenkins Bethan J, Futerman Anthony H
Abstract excerpt
The lysosome is a central player in the cell, acting as a clearing house for macromolecular degradation, but also plays a critical role in a variety of additional metabolic and regulatory processes. The lysosome has recently attracted the attention of neurobiologists and neurologists since a number of neurological diseases involve a lysosomal component. Among these is Parkinson's disease (PD). While heterozygous...
Topics
- Animals
- Brain
- Glucosylceramidase
- Humans
- Lysosomal Storage Diseases
- Lysosomes
- Mutation
- Parkinson Disease
- alpha-Synuclein