Article
AFG2B gene variants and elevated protein expression in lupus nephritis: new insights into childhood-onset systemic lupus erythematosus.
Advances in rheumatology (London, England) - 13 Dec 2025
Kahwage Paola Pinheiro, de Sousa Graziella Ribeiro, de Moura Ronald Rodrigues, Saggioro Fabiano Pinto, Facincani Inalda, Queiroga Denise do Nascimento, Suazo Veridiana Kiill, de Paula Queiroz Rosane Gomes, Aragon Davi Casale, Ferriani Virginia Paes Leme, Sandrin-Garcia Paula, de Carvalho Luciana Martins
Abstract excerpt
BACKGROUND: Previous genome-wide association studies (GWAS) have associated chronic kidney disease with AFG2B variants. The AFG2B protein is linked to key immune-regulating processes through its interaction with proteasome proteins implicated in systemic inflammation. Dysregulation of these processes is a key factor in the onset of childhood-onset systemic lupus erythematosus (cSLE). This study aimed to...
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