Mutations in the gene that encodes the F-actin binding protein anillin cause FSGS.

doi:10.1681/ASN.2013090976

Article

Mutations in the gene that encodes the F-actin binding protein anillin cause FSGS.

Journal of the American Society of Nephrology : JASN - 1 Sept 2014

Gbadegesin Rasheed A, Hall Gentzon, Adeyemo Adebowale, Hanke Nils, Tossidou Irini, Burchette James, Wu Guanghong, Homstad Alison, Sparks Matthew A, Gomez Jose, Jiang Ruiji, Alonso Andrea, Lavin Peter, Conlon Peter, Korstanje Ron, Stander M Christine, Shamsan Ghaidan, Barua Moumita, Spurney Robert, Singhal Pravin C, Kopp Jeffrey B, Haller Hermann, Howell David, Pollak Martin R, Shaw Andrey S, Schiffer Mario, Winn Michelle P

Abstract excerpt

FSGS is characterized by segmental scarring of the glomerulus and is a leading cause of kidney failure. Identification of genes causing FSGS has improved our understanding of disease mechanisms and points to defects in the glomerular epithelial cell, the podocyte, as a major factor in disease pat...

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Mutations in the gene that encodes the F-actin binding protein anillin cause FSGS.

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