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When Genes Meet Gels: Computational Immunogenetics of Dermal Fillers and Stratified Risk of Immune and Fibrotic Reactions across Compositions and Genotypes.

Aesthetic plastic surgery - 1 May 2026

Rahman Eqram, Rao Parinitha, Michon Alain, Ioannidis Sotirios, Wu Woffles T L, Carruthers Jean D A, Webb William Richard

Abstract excerpt

BACKGROUND: Delayed inflammatory and fibrotic reactions to dermal fillers remain unpredictable, reflecting complex interactions between product composition and host genetics. OBJECTIVE: To develop and validate a computational framework integrating filler physicochemical attributes with simulated genetic variation to estimate relative immunologic and fibrotic risk across commercially available products. METHODS:...

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Bayes Theorem
Fibrosis
Genotype
Immunogenetics
Risk Assessment

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 41388170
DOI: 10.1007/s00266-025-05498-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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