Relationship between circadian and social rhythms regulation, chronotype, COMT, CLOCK, GSK3-ß gene polymorphisms and response to valproate treatment in remitted bipolar subjects.

doi:10.1080/07420528.2025.2597961

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Relationship between circadian and social rhythms regulation, chronotype, COMT, CLOCK, GSK3-ß gene polymorphisms and response to valproate treatment in remitted bipolar subjects.

Chronobiology international - 1 Feb 2026

Ulusoy Altinoklu Muge, Baskak Bora, Çakmak Işık Batuhan, Tok Kenan Can, Suzen Halit Sinan

Abstract excerpt

Disruption of social and circadian rhythms (SCRs) is linked to the pathophysiology and course of bipolar disorder (BD). Valproate response in BD is variable and may be influenced by SCRs and genetic polymorphisms. This study investigated the relationship of valproate response with COMT (rs4680), CLOCK (rs1801260), GSK3-ß (rs334558) polymorphisms, SCRs, and chronotype. Ninety-four subjects with BD in remission and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Bipolar Disorder

Catechol O-Methyltransferase

Circadian Rhythm

CLOCK Proteins

Glycogen Synthase Kinase 3 beta

Valproic Acid

Young Adult

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Open in PubMed

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PMID: 41384489
DOI: 10.1080/07420528.2025.2597961

Genes

COMT
CLOCK
SRM

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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