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Article

Causal interplay between trigeminal neuralgia and systemic inflammatory markers: A bidirectional Mendelian randomization study.

Medicine - 23 Jan 2026

Hou Lingsen, Hou Lingbo, Guo Jianwen, Guo Jinzhou, Cui Shanshan

Abstract excerpt

Trigeminal neuralgia (TN) is a debilitating neuropathic pain disorder with profound impacts on quality of life. Although alterations in circulating inflammatory proteins have been reported, observational findings remain inconsistent and are vulnerable to confounding and reverse causation. Whether these immune changes are causal or merely downstream consequences of TN remains uncertain, underscoring the need for...

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PMID: 41578479
DOI: 10.1097/MD.0000000000047243
PMCID: PMC12851747

Genes

CXCL5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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