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Article

The Tbx1 ortholog org-1 is required to establish testis stem cell niche identity in Drosophila.

Development (Cambridge, England) - 1 Jan 2026

Hofe Patrick, Harrington Ariel, Gardner Tynan, DiNardo Stephen, Anllo Lauren

Abstract excerpt

Stem cells require signals from a cellular microenvironment known as the niche that regulates identity, location and division of stem cells. Niche cell identity must be properly specified during development to form a tissue capable of functioning in the adult. Here, we show that the Tbx1 ortholog org-1 is expressed in Drosophila testis niche cells in response to Slit and FGF signals. org-1 is expressed during...

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Testis
Drosophila
Drosophila melanogaster
Drosophila Proteins
Hedgehog Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Stem Cell Niche

T-Box Domain Proteins

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PMID: 41378512
DOI: 10.1242/dev.204914
PMCID: PMC12952371

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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