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Article

Akkermansia muciniphila attenuates sepsis-induced immunosuppression by shaping endotoxin-tolerant macrophage phenotypes.

Pathogens and disease - 30 Jan 2025

Qian Hang, Zhao Fei

Abstract excerpt

Sepsis is a life-threatening condition characterized by immunosuppression, largely mediated by endotoxin tolerance. Akkermansia muciniphila (AKK), a gut probiotic, has been shown to modulate immune responses. In this study, 16S rRNA sequencing revealed decreased AKK levels in immunosuppressed individuals. In vitro experiments using RAW 264.7 macrophages demonstrated that endotoxin tolerance induced an M2...

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Identifiers

PMID: 41363710
DOI: 10.1093/femspd/ftaf013
PMCID: PMC12741952

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