Pasteurized Akkermansia muciniphila ameliorates preeclampsia via inhibiting mitochondrial dysfunction-mediated placental apoptosis in vivo and in vitro

Abstract excerpt

Preeclampsia (PE) is a severe metabolic disorder that occurs during pregnancy and is linked to dysbiosis of the gut microbiota, characterised by a decrease in Akkermansia muciniphila (AKK). Emerging evidence suggests that pasteurized Akkermansia muciniphila (pAKK) is a promising candidate for preventing or treating obesity-related metabolic disorders. However, the modulatory function and the underlying mechanisms...

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