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Exploring the genetic architecture of multiple long-term conditions using a genome-wide association study in the UK Biobank population.

Scientific reports - 6 Dec 2025

Nair Anand Thakarakkattil Narayanan, Witham Miles, Sayer Avan A, Cordell Heather J, Pearson Ewan R

Abstract excerpt

The prevalence of multiple long-term conditions (MLTC) is increasing. It is essential to develop strategies to prevent and manage MLTC; however, the biological mechanisms underlying MLTC are not yet clearly understood. We used UK Biobank data as part of the ADMISSION research collaborative to identify genetic drivers for MLTC. We used the UK Biobank (UKBB) self-reported illness data to characterise MLTC (defined...

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Identifiers

PMID: 41353206
DOI: 10.1038/s41598-025-27839-4
PMCID: PMC12715236

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