Article
Allele-specific zinc metalloprotease B influences cardiac damage during invasive pneumococcal disease.
Cell reports - 23 Dec 2025
Luck Jennifer N, D'Mello Adonis, Chembilikandy Vipin, Lane Jessica R, Kruckow Katherine, Martínez Eriel, Rodriguez Efrain, Mohasin Mohammed, Berg Ian, Porter Katherine D, Sethu Palanappian, Tettelin Hervé, Orihuela Carlos J
Abstract excerpt
During severe infection, Streptococcuspneumoniae invades the myocardium, causing life-threatening cardiac complications. Bacterial genome-wide association studies implicate a specific allele of the gene encoding zinc metalloprotease B (ZmpB) as a key determinant of S. pneumoniae-mediated cardiac damage. In mouse models, ZmpB-deficient S. pneumoniae show reduced cardiac microlesion formation, and immunization with...
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