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Article

Virus-induced APOBEC3 transmutagenesis in bladder cancer initiation.

Science advances - 5 Dec 2025

Hatton George H, James Sally R, Mason Andrew S, Gawne Richard T, Vogel Helena, Hogg Karen, Boukani Parisa, Swinscoe Gemma, Khan Anjum, Welberry Smith Matthew, Carpenter Michael A, Masood Omar, Martincorena Iñigo, Macdonald Andrew, Harris Reuben S, Starrett Gabriel J, Southgate Jennifer, Baker Simon C

Abstract excerpt

Carcinogenesis in human urothelium is driven by a high burden of mutations caused by the antiviral "APOBEC3" (apolipoprotein B mRNA editing enzyme, catalytic subunit-like 3) cytosine deaminase enzymes; however, there is no established viral etiology. BK polyomavirus (BKPyV) is a ubiquitous childhood infection that persists in the kidney during adulthood and is frequently detected in urine. Chronic BKPyV...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41337590
DOI: 10.1126/sciadv.aea6124
PMCID: PMC12674112

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Virus-induced APOBEC3 transmutagenesis in bladder cancer initiation.PMID 41337590Read ↗

Induction of APOBEC3-mediated genomic damage in urothelium implicates BK polyomavirus (BKPyV) as a hit-and-run driver for bladder cancerSemantic proximity Read ↗

BK polyomavirus (BKPyV) is a risk factor for bladder cancer through induction of APOBEC3-mediated genomic damageSemantic proximity Read ↗

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Analysis of Several Common APOBEC-type Mutations in Bladder Tumors Suggests Links to Viral Infection.Semantic proximity Read ↗

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