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Article

How to treat BRAF mutant metastatic melanoma?

Personalized medicine - 1 Dec 2025

Sini Maria Cristina, Casula Milena, Pisano Marina, Palmieri Giuseppe, Manca Antonella

Abstract excerpt

Melanoma is a malignant tumour arising from melanocytes and is the most aggressive type of skin cancer. In advanced disease standard treatments are largely ineffective. About 40% of cutaneous melanomas carry BRAF mutations-more common in younger patients-and these are linked to more aggressive behaviour and a higher risk of brain metastasis. Over the past decade, targeted therapies (TT) using BRAF and MEK...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41321021
DOI: 10.1080/17410541.2025.2595903

Genes

BRAF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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