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Article

Beyond BRAF: where next for melanoma therapy?

2 Sept 2014

Abstract excerpt

In recent years, melanoma has become a poster-child for the development of oncogene-directed targeted therapies. This approach, which has been exemplified by the development of small-molecule BRAF inhibitors and the BRAF/MEK inhibitor combination for BRAF-mutant melanoma, has brought new hope to patients. Despite these successes, treatment failure seems near inevitable in the majority of cases—even in individuals...

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PMID: 25180764
DOI: 10.1038/bjc.2014.476

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