Braf-Mutant Melanomas: Biology and Therapy

Abstract excerpt

The incidence of melanoma, the most lethal form of skin cancer, has increased due to ultraviolet exposure. The molecular characterization of melanomas has shown a high mutational burden led to the identification of some recurrent genetic alterations. BRAF gene is mutated in 40-50% of melanomas and its role in melanoma development is paramount. BRAF mutations confer constitutive activation of MAPK signalling. The l...

Topics

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• Computational Drug Discovery Methods
• Cutaneous Melanoma Detection and Management
• Melanoma
• Melanoma and MAPK Pathways
• Molecular Targeted Therapy
• Mutation
• Proto-Oncogene Proteins B-raf
• Skin Neoplasms

Identifiers and source

Literature Corpus work

d128d40a-6003-525f-96ef-8979112e7928

DOI

10.20944/preprints202410.2428.v1