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Article

Braf-Mutant Melanomas: Biology and Therapy.

Current oncology (Toronto, Ont.) - 3 Dec 2024

Pelosi Elvira, Castelli Germana, Testa Ugo

Abstract excerpt

The incidence of melanoma, the most lethal form of skin cancer, has increased mainly due to ultraviolet exposure. The molecular characterization of melanomas has shown a high mutational burden led to the identification of some recurrent genetic alterations. BRAF gene is mutated in 40-50% of melanomas and its role in melanoma development is paramount. BRAF mutations confer constitutive activation of MAPK...

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Identifiers

PMID: 39727691
DOI: 10.3390/curroncol31120568
PMCID: PMC11674697

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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