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Article

5T chemical exchange saturation transfer imaging improves glioma grading and genotyping prediction: a supplement to 3T diffusion and perfusion MRI.

Journal of translational medicine - 28 Nov 2025

Zhou Jie, Xu Dan, Sun Wenbo, Yang Chao, Sun Mengqi, Li Tianliang, Song Xiaopeng, Mao Wei, Li Ruolan, Cai Yuxiang, Ma Chao, Topgaard Daniel, Li Huan, Xu Haibo

Abstract excerpt

BACKGROUND AND PURPOSE: Accurate grading and genotyping of gliomas are critical for tailoring personalized therapeutic strategies and predicting patient outcomes. This study investigates the potential of 5T glutamate chemical exchange saturation transfer (GluCEST) imaging in differentiating glioma grades and predicting pivotal molecular biomarker status. METHODS: We first validated the specificity of GluCEST...

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Identifiers

PMID: 41316315
DOI: 10.1186/s12967-025-07464-5
PMCID: PMC12859950

Genes

EGFR
MGMT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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