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Article

Genetic Crosstalk Between Type 1 Diabetes and Sjögren's Syndrome: A Systematic Exploration of Risk Genes and Common Pathways.

Journal of cellular and molecular medicine - 1 Nov 2025

Fahira Aamir, Zhuang Kai, Jian Xuemin, Jan Syed Mansoor, Liu Yong, Sun Jianbo, Shi Yongyong, Huang Zunnan

Abstract excerpt

Sjögren's Syndrome (SS) and Type 1 Diabetes (T1D) are autoimmune disorders that can co-occur in patients, leading to complex clinical presentations. Despite observational evidence of their co-occurrence, the underlying genetic mechanisms remain poorly understood. To investigate the shared genetic factors and pathways between SS and T1D, we conducted a comprehensive analysis using multiomic approaches. Conditional...

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Source

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Identifiers

PMID: 41294018
DOI: 10.1111/jcmm.70930
PMCID: PMC12648307

Genes

CERS2
CRHR1
DEF6
PLEKHM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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