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Characterization of primary Sjögren's syndrome in the Taiwan Han population through a genome-wide association study and polygenic risk score analysis.

Clinical immunology (Orlando, Fla.) - 1 Dec 2024

Liu Ting-Yuan, Lin Min-Rou, Lu Hsing-Fang, Chen Yu-Chia, Lin Hui-Ju, Chou Wan-Hsuan, Wei Chun-Yu, Palupi Poppy Diah, Liao Chi-Chou, Chang Yen-Ting, Chang Wei-Chiao, Tsai Fuu-Jen

Abstract excerpt

BACKGROUND: Sjögren's syndrome (SS) is an autoimmune disorder that primarily affects the exocrine glands, leading to dryness of mucous membranes and systemic manifestations. This study aimed to identify genetic markers associated with primary SS (pSS) in the Taiwan Han population through a hospital-based genome-wide association study (GWAS) and polygenic risk score (PRS) analysis, addressing the lack of genetic...

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PMID: 39437979
DOI: 10.1016/j.clim.2024.110381

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