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Article

Intrinsic Motoneuron Excitability Differentiates Sarcopenic, Nonsarcopenic and Athletic Ageing Phenotypes.

Journal of cachexia, sarcopenia and muscle - 1 Dec 2025

Orssatto Lucas B R, Scott David, Clark Brian C, Lim Jeffrey, Daly Robin M

Abstract excerpt

BACKGROUND: The mechanisms underlying sarcopenia-related physical decline remain poorly understood, particularly with respect to neural contributions. Muscle atrophy has traditionally been viewed as the primary driver, but growing evidence suggests that neuromuscular impairments-especially reduced intrinsic motoneuron excitability-may play a central role. This intrinsic excitability, which is critical for...

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Identifiers

PMID: 41292210
DOI: 10.1002/jcsm.70126
PMCID: PMC12647921

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